A Cavendish Square Group publication 59 Latest research undertaken by the Trust The Trust is one of the first in the UK to open a clinical trials facility specifically for mental health research. The new purpose-built facility, on the Lakeside Mental Health Unit site in Isleworth, is needed due to the wide range of clinical trials work the trust is carrying out into dementia, psychosis and personality disorder. The Trust conducted or participated in 85 research studies last year with 957 patients participating. Staff published 86 articles in peer-reviewed journals. The AFFECT Study AFFECT is our first medication trial for people with a diagnosis of Vascular Dementia. This study is being funded by the Alzheimer’s Society and the British Heart Foundation. 135,000 people in the UK have a diagnosis of Vascular Dementia, and there is currently no approved treatment. The AFFECT study is testing a medication called Amlodipine, which is normally given to people who have high blood pressure. Research suggests this medication may be useful in improving the health of people who have a diagnosis of Vascular Dementia. Half of the people in the study will take Amlodipine and half will take a placebo (a dummy drug). Deep and Frequent Phenotyping This innovative study is part of David Cameron’s pledge for the Dementias Platform UK, a £53million investment in dementia research. The study involved conducting in depth diagnostic tests, including brain scans and questionnaires to find out more about people’s memory, blood tests, and lumbar puncture. The study aims to tell us more about the best, most accurate way to diagnose people with Alzheimer’s Disease. PREVENT The PREVENT study aims to gather information about what factors may increase a person’s risk for developing dementia later in life. The Trust is working with healthy people who are aged 40 to 59 who either have a history of dementia in their family or not. In addition to its drugs trials, the Trust is working with South London and Maudsley NHS Foundation Trust (SLAM), Camden and Islington NHS Foundation Trust (Candi), and the universities of Oxford and Cambridge in piloting CRIS, a prestigious project to develop an information tool that mines anonymised patient data for mental health research purposes.
London Mental Health Fact Bbook
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