A Register for New Anti-Epileptic Drugs in ID/PDD populations

IRAS# 345110

Summary: This Epilepsy Research Database is focussed on building an ongoing evidence base evaluating the outcomes of Anti-Epileptic Drugs and epilepsy treatments for people with Intellectual Disability (ID) and/or Pervasive Developmental Disorders (PDD such as Autism). This involves collecting data for all people with epilepsy (Those with and without an ID and/or PDD). All patients currently or previously prescribed an Anti-Epileptic Drug (or epilepsy treatment) which is part of a live arm of the Research Database Register are therefore eligible to participate

Chief Investigator: Dr Rohit Shankar

Principal Investigator: Anna Cattrell

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ACER V1.0

IRAS #311434

Summary: Mental health rehabilitation services provide specialist treatment to people with particularly severe and complex problems. These services include inpatient units and supported accommodation in the community. When people have access to local rehabilitation services, most gain the skills to manage with less support over time, progressing from inpatient care to supported accommodation. However, over the last 15 years there have been major cuts to NHS rehabilitation services across England and increasing reliance on the independent sector. The Care Quality Commission reported in 2018 that over half the 4400 mental health inpatient rehabilitation beds in England were provided by the independent sector. They raised concerns that people were staying twice as long compared to people treated in NHS rehabilitation units and they were much further from their home. However, we do not know whether the services provided by the NHS and independent sector differ in quality or patient outcomes. There have been no studies investigating the effectiveness of inpatient rehabilitation services that have included the independent sector. This project, funded by the NIHR Health Services Delivery Research, aims to address this gap.

Chief Investigator: Dr Helen Killaspy

Principal Investigator: Professor Joanna Moncrieff

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ACT for older people with TR-GAD (CONTACT-GAD)

IRAS #320523

Summary: Generalised anxiety disorder (GAD), characterised by a tendency to worry, is the most common anxiety disorder in older people. Medication and talking therapy are usually offered as forms of treatment, but many do not find them helpful. Guidance on how to help older people manage GAD when it does not respond to such treatments is lacking. In a previous study (FACTOID), we developed and tailored a talking therapy intervention to the psychological, physical and cognitive needs of older people with treatment-resistant GAD (TR GAD). This was based on Acceptance and Commitment Therapy (ACT); a form of talking therapy that helps people learn how best to live with distressing thoughts, feelings and sensations, while still doing things that really matter to them. This showed that tailored ACT was acceptable to older people with TR-GAD and it may help improve anxiety, depression and coping. The aim of CONTACT-GAD is to find out whether tailored ACT is helpful for older people with TR-GAD and whether it represents value for money in a larger clinical trial.

Chief Investigator: Dr Rebecca Gould

Principal Investigator: Dr Georgina Charlesworth

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ASsuRED Trial V1

IRAS #279991

Summary: When someone who has harmed themselves is seen in the Emergency Department (ED), a mental health practitioner (MHP) conduct a risk assessment. This includes assessing the patient’s psychological state, social situation and needs for support. However, referring patients to specialized mental health services is often not a realistic option because of limited capacity in services, lengthy waitlists and many patients do not attend or withdraw from treatment. Risk of suicide is greatest in the initial week after discharge from hospital, so rapid follow up care in the days following discharge has the potential to provide a lifesaving intervention for people. This study is testing an intervention of a therapeutic assessment, a check-in phone call within 72-hours and three follow-up sessions using a solution focused approach to see if the intervention is effective compared with usual practice in reducing reattendance to hospital for self-harm. 

Chief Investigator: Professor Rose McCabe

Principal Investigator: Dr Luca Polledri

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BPD/ASPD - Probing Social Exchanges – A Computational Neuroscience Approach to the Understanding of Borderline and Anti-Social Personality Disorder 

IRAS #103075

Summary: The study aims to investigate the brain activation patterns of people suffering from personality disorders (both in adults and adolescents) or similar traits and compare them with healthy control participants. Only little is known about the neurobiology of Borderline and Antisocial Personality Disorders. The study design will address some of these which will hopefully allow us to gain a better understanding of the disorders and to develop more informed and effective treatments from which clients will benefit.

Chief Investigator: Professor Peter Fonagy 

Principal Investigator: Dr Janet Feigenbaum         

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CBT and the Neural Circuits of Anxiety

IRAS #255501

Summary: The impact of CBT on threat-potentiated neural circuitry Pathological feelings of anxiety constitutes the most common psychiatric diagnosis in the developed world, yet current psychological treatments are largely clinically ineffective. CBT (cognitive behavioural therapy) is a structured form of psychological therapy, and can be successful for some individuals, but its neurobiological mechanism of action remains unknown. This study will aim to test whether specific neural circuitry changes, proposed on the basis of our neurocognitive model of anxiety, are a mechanism of action for CBT interventions. This study also aims to elucidate the neurobiological mechanisms of CBT’s therapeutic effect and potentially allow for more targeted/specific approaches to anxiety disorders. The ultimate aim is to improve the efficacy of CBT, and more generally, psychological interventions for anxiety disorders.

Chief Investigator: Dr Oliver J Robinson

Principal Investigator: Aitziber Elizalde

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Cognitive and Neural Networks in Psychiatry

IRAS #184289

Summary: The Cognitive and Neural Networks in Psychiatry (CNNP) Study investigates the neural and cognitive mechanisms that are associated with psychiatric disorders. Despite the frequent occurrence and the high costs associated with psychiatric disorders, little is known about the mechanisms causing these illnesses and what prevents people from becoming mentally ill. The CNNP study investigates the neurocognitive aspects of psychiatric disorders, the validity of a dimensional approach and trans­-diagnostical traits.  The study will investigate key psychiatric dimensions, such as impulsivity, compulsivity, emotional instability and social difficultiesThe CNNP is part of the Neuroscience in Psychiatry Network (NSPN), funded by a Strategic Wellcome Trust Award. 

Chief Investigator: Professor Ray Dolan

Principal Investigator: Aitziber Elizalde

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EDGI 

IRAS# 243566

Summary: Eating Disorders Genetics Initiative (EDGI) will be the world’s first comprehensive resource for eating disorders and will provide: (1) biological samples for studying the genetics (2) psychological and medical data, including neuropsychological, psychiatric conditions and medical comorbidities; and (3) data on family psychiatric and medical history. It will represent a resource of clinical measures linked to biological samples as part of the NIHR BioResource

and the NIHR BioResource Centre Maudsley. The resource will enable studies on EDs by providing samples and biological data to the scientific community at minimal costs.

Chief Investigator: Professor Gerome Breen

Principal Investigator: Dr Anna Oldershaw

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Genetic Links to Anxiety and Depression (GLAD)

IRAS# 245339

Summary: The aim of this project is to recruit a large number of participants who will provide responses to a comprehensive set of questions. They will be recruited into an existing biobank, the NIHR BioResource for Translational Research in Common and Rare Diseases, a recontactable biobank. This will help towards forming the largest recontactable biobank of participants diagnosed with or suffering from two very common disorders, depression and anxiety, who will be primarily recruited through an online platform. The project will explore genetic and environmental factors associated with risk for depression and anxiety disorders in the UK, to understand these common disorders and help develop better treatments. 

Chief Investigator: Professor Gerome Breen

Principal Investigator: Dr Russell Razzaque

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MDD - Probing Social Exchanges and Emotions– A Computational Neuroscience Approach to the Understanding of Major Depressive Disorder

IRAS# 161423

Summary: This study aims to investigate the brain activation patterns of people suffering from Major Depressive Disorder and compare them with healthy control participants as little is known about the neurobiology of Depression. The study design will aim to address some of these gaps in current knowledge and so enable a better understanding of the disorder and contribute toward developing more informed and effective treatments from which clients will benefit.

Chief Investigator: Professor Read Montague

Principal Investigator: Aitziber Elizalde

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Medication management in EiPS: Exploring SDM

IRAS# 323185

Summary: The overall aim of this study is to explore how medication for mental health is managed in relation to Shared Decision Making (SDM) principles in Early Intervention for Psychosis Services (EIPS), in order to inform improvements to patients' involvement in care. EIPS are specialist services for people who experience psychosis for the first time, which offer support for up to three years. SDM, which is recommended in recent NICE guidelines for all forms of healthcare, refers to the collaboration between two ‘experts’, the clinician (an expert on evidence-based treatment options) and the service user (an expert in personal experiences and preferences), to come to a decision on treatment. Mental health has lagged behind other areas of medicine in implementing SDM, so research exploring how this can be developed and embedded within clinical practice is timely.

Chief Investigator: Dr Joanna Moncrieff

Principal Investigator: Dr Joanna Moncrieff

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MoreRESPECT

IRAS# 309345

Summary: People with severe mental illness (SMI) have significant unmet needs in terms of physical health when compared to the general population. Initiatives have commenced to address this; however, sexual health has been missed off the agenda. Positive sexual relationships are important for people with SMI, but this is rarely discussed in routine mental health care. Therefore, they can be unaware of important information such as where to get sexual health advice, how to reduce risk of sexually transmitted infections, contraceptive choices and finding relationships that are mutually respectful; rather than exploitative and abusive. The moreRESPECT study builds on the learning from the RESPECT feasibility study, which established the safety, feasibility and acceptability of undertaking a randomised controlled trial of this intervention in this population. In this study, we will aim to answer the research question: is an intervention to promote sexual health for people with SMI clinically and cost-effective?

Chief Investigator: Dr Elizabeth Hughes

Principal Investigator: Mark Leach

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NCISH – National Confidential Inquiry into Suicide and Homicide by People with Mental Illness

IRAS# 0
NIHR# 5656

Summary: This study aims to collect detailed clinical information on patients of mental health services who die by suicide, or commit homicide.  It also aims to make recommendations for policy and clinical practice.  

Chief Investigator: Professor Louis Appleby

Principal Investigator: Dr Sandeep Toot

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PEGASUS Feasibility study

IRAS# 326517

Summary: People with a severe mental illness (SMI) such as schizophrenia or bipolar disorder can die 15-20 years younger than the general population. Cardiovascular disease (CVD), including heart disease, is the biggest cause of early death in people with SMI. People with SMI can experience weight gain from anti-psychotic medication, social isolation and poor integration between mental and physical health services. People from Black and minority ethnic communities can be affected by increased rates of both SMI and CVD. We aim to reduce risk of CVD in all people with SMI. In this study we feasibility test a trained peer-led group clinic intervention for people with severe mental illness (SMI) who have metabolic syndrome, i.e. a risk-indicator of cardiovascular disease (CVD). Building upon research evidence of effective multi-goal interventions, the PEGASUS research programme is co-producing a group clinic co-facilitated by clinicians and peer workers. The intervention will offer personalised, goal-oriented exercise and diet advice and supported to work towards their own health goals.

Chief Investigator: Jacqueline Sin

Principal Investigator: Professor Joanna Moncrieff

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PPiP2 - Prevalence of Neuronal cell surface antibodies in patients with Psychotic illness - extension study. Determining the Clinical relevance of Pathogenic Antibodies in Psychosis

IRAS# 97740

Summary: The study aims to understand if some cases of psychosis are caused by immune system problems in some people. The immune system normally controls our ability to fight infection. If the immune system goes wrong, it may cause diseases called ‘autoimmune’ diseases. However, diagnoses can be made for some of these autoimmune diseases using blood tests. The study will specifically focus on antibodies affecting the N-methyl D-aspartate receptors (NMDA-r) or other neuronal membrane targets that may be the cause symptoms of psychosis and possibly cause some cases of schizophrenia. 

Chief Investigator: Dr Belinda Lennox

Principal Investigator: Dr Dinesh Kumar

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Routine screening for gambling-related harm

IRAS 335673

Summary: Over half of adults in the UK gamble; but nearly two million of these suffer problems such as debt, relationship troubles, and mental health problems. Most people who experience gambling harms do not ask for help or get sent for treatment. However, people do ask for help with other issues such as depression or problem alcohol use from places such as Community and NHS Mental Health Services or Charities such as We Are With You. Would these services be able to ask people about gambling, to find out if they are experiencing gambling harms and then refer them for treatment? Currently people working in these services do not ask. This study will involve interviews and focus groups with individuals to find out if staff and patients in those services are happy to talk about gambling. We will find out what may help people talk about it. We will also find out the best way of checking for gambling harms. The project will hopefully find a way to help more people suffering from gambling-related harm by identifying them and referring them for treatment.

Chief Investigator: Dr Amanda Robert

Principal Investigator: Syeda Begum

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Service configurations for psychosis

IRAS# 329320

Summary: Psychosis is a term for experiences such as hearing disturbing voices or extreme suspiciousness. There is increasing recognition that long-lasting stress and childhood experiences can play a role in causing psychosis. Research suggests it is helpful when services offer a range of therapies, involve people’s family or friends, and support people's life goals. However, precisely how this works is unclear, and not enough people have access to this type of service, especially ethnic minorities. This research will use research and lived experience to explain how people draw on services, friends, family and other support to achieve their own definition of recovery. We will work with stakeholders (service providers, experts by experience and informal carers) to suggest how services can improve recovery across ethnicities, then plan service changes with stakeholders. We will bring together research and stakeholder experience to produce explanations of how services enable recovery – ‘programme theories’. 

Chief Investigator: Ms Sue Holltum

Principal Investigator: Dr Russell Razzaque

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STORY – Stages, Progression, and Recovery of Eating Disorders in Youth

IRAS# 325803

Summary: A comprehensive understanding of how EDs progress and the factors that influence the recovery process is important in informing targeted preventative interventions. In order to advance the evidence base, longitudinal research unconfounded by the developmental stage is required. STORY aims to compare the biopsychosocial symptom profiles and behavioural and brain responses of those with early- and later-stage EDs, both within and between diagnoses. STORY also aims to understand the details of the recovery process in those with early-stage EDs by collecting multifaceted real-time data using remote measurement technologies (RMT) over an ongoing period of 12 months.

Chief Investigator: Professor Ulrike Schmidt

Principal Investigator: Dr Lucy Serpell

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VISION-QUEST

IRAS# 332680

Summary: One in three people with psychosis experience distressing visual hallucinations (VH).  When VH occur, they can have a detrimental impact on people’s lives, such as more frequent and prolonged hospital admissions, and greater likelihood of suicide. A previous study by this team people with VH found that the way in which people make sense of their VH are one of the keys factors driving distress. The next step is to explore this on a larger scale to understand more about people’s appraisals of VH. Then this can be used to validate a scale of VH appraisals and develop targeted treatments for these. This study will develop a questionnaire focused on people’s beliefs about VH. It will also explore the relationship of visions to other potential casual mechanisms such as poor sleep, and excessive worry.

Chief Investigator: Charlotte Aynsworth

Principal Investigator: Dr Anna Cattrell

Strengthening programme for ambulant adolescents with cerebral palsy ROBUST

IRAS# 325313

Summary: Cerebral palsy (CP) is caused when babies suffer brain injury from lack of oxygen in the brain. Children with CP often develop stiff muscles. They often have difficulty walking and moving and that makes it difficult for them to join in many different activities. It is possible that a programme of exercises to stretch their leg muscles could prevent stiffness and help them remain more active. We are not certain that children with CP truly benefit from the time and effort they dedicate to doing these exercises. We are also not sure if this exercise might cause them too much discomfort/muscle soreness to be able to carry it out long-term. The aim of this study is to assess if an exercise programme to stretch the muscles of children with CP is better than usual NHS physiotherapy treatment. We hope the results produced will be adopted widely by health professionals and help policy makers develop national guidelines for physiotherapy treatment of children with CP.

Chief Investigator: Sally Hopwell

Principal Investigator: Dr Anna Cattrell

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Stimulant Medication for ADHD and Tics - Understanding Response versus Non-stimulants (SATURN)

IRAS #1005480

Summary: In the UK,3-5% of children and young people (CYP) have attention deficit hyperactivity disorder (ADHD). Out of those,1 in 5 also experience tics. Stimulant medication is effective for ADHD,however,there is concern among doctors that it may worsen children/young people’s tics. As a result,they prefer to prescribe non-stimulants which may be less effective for ADHD to CYP who suffer from both ADHD and tics. The aim of the SATURN trial is to understand whether stimulant or non-stimulant medication is the most effective in children and young people (6-16 years old) with ADHD and tics.

Chief Investigator: Professor Chris Hollis

Principal Investigator: Dr Holan Liang

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Stretching programme for ambulant children with cerebral palsy (SPELL)

IRAS# 326645

Summary: Cerebral palsy (CP) is caused when babies suffer brain injury from lack of oxygen in the brain. Children with CP often develop stiff muscles. They often have difficulty walking and moving and that makes it difficult for them to join in many different activities. It is possible that a programme of exercises to stretch their leg muscles could prevent stiffness and help them remain more active. We are not certain that children with CP truly benefit from the time and effort they dedicate to doing these exercises. We are also not sure if this exercise might cause them too much discomfort/muscle soreness to be able to carry it out long-term. The aim of this study is to assess if an exercise programme to stretch the muscles of children with CP is better than usual NHS physiotherapy treatment. We hope the results produced will be adopted widely by health professionals and help policy makers develop national guidelines for physiotherapy treatment of children with CP.

Chief Investigator: Dr Anna Cattrell

Principal Investigator: Professor Tim Theologis

CareCoach Study

IRAS# 338454

Summary: People who care for people living with dementia (who we refer to as carers or caregivers) need to have information and skills to manage and support the day-to-day care they provide. The aim of this study is to test the effects of using an online support package for carers called CareCoach. In other words, the study will test whether CareCoach has an effect on carer’s sense of being able to care well, their mood and quality of life.

Chief Investigator: Christopher Fox

Principal Investigator: Jane Burgess

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Compassion Focused Therapy - for Mood in Dementia (Version 1.0)

IRAS# 327086

Summary: Of the 850,000 people with dementia in the UK, many experience depression, anxiety or both. This can worsen cognition (e.g. memory and language) and behavioural problems, lead to relationship difficulties, and increase care home admissions. With medications for mood in dementia often ineffective, recent trends have moved towards non-drug interventions. However, the lack of interventions available with proven effects results in significant unmet needs. Compassion Focused Therapy (CFT) is a talking therapy, which addresses feelings of shame and stigma. This study aims to understand whether CFT is acceptable as an intervention for people with dementia and depression/ anxiety and whether conducting a future full-scale trial is likely to be possible.

Chief Investigator: Dr Georgina Charlesworth

Principal Investigator: Lindsay Royan

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DIADEM

IRAS# 333204

Summary: This study uses a simple hearing test that measures subtle changes in the brain. The study team have expertise in auditory neuroscience, early detection of dementia, and the diagnostic pathway in NHS memory clinics. It typically takes over three years to get a dementia diagnosis from the time symptoms start. Timely and accurate diagnosis will be vital to ensure access to future treatments that may be able to slow down dementia. However, current diagnostic tests are ‘blunt’ and expensive. Those who are more deprived or from minoritised ethnic groups tend to be diagnosed later and less accurately. This study will evaluate digital hearing tests in a “real-world” setting in memory clinics that serve a diverse and deprived population. It will assess how well hearing tests can identify patients with dementia at initial assessment, and follow patients for 2 years to establish how well the test predicts dementia in those who did not receive a diagnosis of dementia initially.  The technology is designed to be a cost-effective decision support tool that could be used throughout the NHS.

Chief Investigator: Dr Charles Marshall

Principal Investigator: Dr Harsh Garekar

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DEMSA V1.0

IRAS# 320061

Summary: The NHS emphasises the importance of person-centred care for people with dementia, yet there is a lack of culturally appropriate dementia care for ethnic minorities and little research into how person-centred care is experienced by these communities. Most dementia care in South Asian communities in the UK is provided at home by family carers. Despite this, there is low uptake of care planning amongst ethnic minorities. This highlights the importance of understanding the care environment and the impact of cultural factors, and how these interact to produce distinct experiences of person-centred care.  This study will explore what ‘person-centred care’ means for South Asian people with dementia, explore how care planning discussions take place in the community and how care environments can be culturally adapted to ensure optimal person-centred care.

Chief Investigator: Dr Nathan Davies

Principal Investigator: Ritchard Ledgerd

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NIDUS

IRAS# 271363

Summary: This study is funded by the Alzheimer’s Society and led by University College London in collaboration with University of Bradford (UoB). This application is for the full trial of part three of a large programme of work. In part one, we carried out interviews and observations with family carers, people with dementia and professionals on what helps and hinders independence at home. We used our findings to co-produce a psychological intervention to improve the support received by people with dementia and their family/friend at home. We piloted the intervention to make sure it was acceptable to the participants receiving it and the researchers delivering it. We will now test whether the intervention works.

Chief Investigator: Professor Claudia Cooper

Principal Investigator: Ritchard Ledgerd

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NOLA

IRAS# 325387

Summary: Receiving a diagnosis of dementia can be traumatic. Despite this, emotional support that helps a person with dementia and their family process and adapt to a diagnosis is minimal in NHS services. As such, a post-diagnostic intervention to help people process and adjust to a diagnosis of dementia, increasing their wellbeing, is urgently needed. This study will conduct qualitative research using two Work Packages (WP). WP1 includes a national, online survey of people living with dementia and carers across the UK to better understand their experiences of receiving a diagnosis, what support they are offered and what they require from a new intervention that aims to help them process and adjust to the diagnosis. This national survey will be complemented by in-depth, in-person interviews with people with dementia and carer. WP2 will conduct focus groups and interviews with three groups of participants: 1) healthcare managers/decision makers/policy professional/ community leaders, 2) healthcare and research professionals, and 3) people living with dementia and informal carers. The purpose of WP2 will be to understand what may help or stop implementation of an intervention in UK memory clinics. This will help develop strategies that mean the intervention can be used across the UK.

Chief Investigator: Dr Charlotte Stoner

Principal Investigator: Jane Burgess

ESMI III

IRAS# 265175 

TBC

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Genes and Health

IRAS# 146051

Summary : In East London [and second site Bradford], South Asian people have some of the highest rates of heart disease, diabetes, and poor health in the UK. Living with a long-term illness has a major impact on a person’s quality of life and on their family. Genes & Health is a medical research study set up to help fight against these and other major diseases. Some early aims of the study are to study normal variation in genes in adult Bangladeshi and Pakistani people, to study genes in people with very high and very low cholesterol levels, to better understand why heart disease and stroke occurs, to study variation in genes in healthy adults whose parents are related, and to study genes of people with diabetes. 

Chief Investigator: Professor David Van Heel

Principal Investigator: Dr Sandeep Toot

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Harnessing portable smart-camera technology for people with aphasia (HARP)

IRAS# 333814

Summary: Aphasia is a communication disorder caused by damage to the brain. It can make it hard to talk, understand, read and write, affecting a person’s social life, ability to work and wellbeing. About 350,000 people in the UK have aphasia. Speech and Language Therapy helps people with aphasia to improve their communication skills and manage their condition independently. Technology can be used to practise communication skills and overcome difficulties. “Smart cameras” can take pictures of text and read it out loud for people who struggle with reading. They can also recognise faces, learn people’s names, and describe things. This technology is portable and relatively cheap (e.g. smartphone apps). It is designed for people with visual impairment. We don’t yet know how useful or user-friendly it is for people with aphasia. This study aims to use existing smart-camera technology in a new way to help people with aphasia improve their spoken language and reading. 

Chief Investigator: Mark Allinson

Principal Investigator: Dr Anna Caute

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PD Frontline (RAPSODI GD)

IRAS# 173275

Summary: This project aims to remotely detect the early signs and symptoms of Parkinson's disease (PD) in a group of patients who carry a gene (glucocerebrosidase-GBA) which causes a genetic predisposition to it. We aim to detect these signs and symptoms prior to the clinically diagnostic onset of the movement related (motor) symptoms of the disease. We will assess for signs and symptoms including anxiety, depression, bradykinesia (slowness of movement), cognitive decline, reduced sense of smell, abnormal sleep behaviours, constipation and erectile dysfunction associated with the very early stages of PD. Under most circumstances the study will be undertaken entirely at the participant's home, either through an internet portal or with the use of postal assessments. We intend that this study will enable us to understand and describe the early stages of PD in this patient group and provide insights into the genetic risk factors that contribute to it.

Chief Investigator: Professor Anthony Schapira

Principal Investigator: Dr Anna Cattrell

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REABLE-M: Reablement models for better outcomes

IRAS# 331518

Summary: When people leave hospital, they often need short term support in the community to help them regain abilities to wash and dress themselves, cook, shop or take part in social activities. This kind of support is called ‘reablement’. Reablement workers focus on doing activities with, not for, people. Reablement has been around for over a decade, but we are unsure how well it works. We do not know if it works better for some people than others and why, or if the length of time people have support makes a difference. We also do not know much about the type of training that reablement workers get and whether this makes a difference to the experiences and outcomes of the people they are working with. We want to find out which types of reablement help people the most when they leave hospital. This project will seek to understand the support that people and their carers are getting from reablement and other services and assess the explore the experiences of underserved groups.  We will try to establish which type of reablement is the best and for whom, and which is the best value for money.

Chief Investigator: Dr Catherine Henderson

Principal Investigator: Dr Catherine Henderson

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TONIC Phase 2, 3, 4 and 5

IRAS# 88372

Summary: Quality of Life (QoL) for people with disabling neurological conditions is affected by a range of factors, which have received considerable previous research attention. However clinicians’ knowledge could be enhanced.  This study will consult with a range of people with the conditions stroke, traumatic brain injury, multiple sclerosis, neuromyelitis optica, spinal conditions and motor neurone disease to learn about QoL and develop and test a questionnaire measure.

Chief Investigator: Professor Carolyn Young

Principal Investigator: Liz Edmonds

TBC

A clinical and cost effectiveness RCT of iACT4CARERS

IRAS# 324157

Summary: Family carers are at higher risk of developing anxiety and depression. Offering treatments online improves availability for people who have mobility problems, live remotely or cannot leave home. This makes it more accessible to everyone and easier to provide, so could be rolled out nationally, reducing inequalities in access to care. This large trial aims to find out if internet-delivered self-help Acceptance and Commitment Therapy (ACT) for family carers of people with dementia (online ACT) is helpful in reducing anxiety and affordable.  It also aims to find out how online ACT can be successfully delivered to diverse carer populations and in different healthcare settings.

Chief Investigator: Dr Naoko Kishita

Principal Investigator: Jane Burges

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ABATED

IRAS# 312683

Summary: People are referred to memory clinics when there is a suspicion that they might have dementia. However, there are other causes of memory difficulty, and often it is impossible to know whether someone has dementia when they are first assessed. Doctors refer to this uncertain situation as “mild cognitive disorder” (MCD). Currently, the only way to establish the diagnosis is to follow people over time to see if things get worse. Timely diagnosis is important. Brain scans are a routine part of memory clinic assessment. Dementia causes shrinking of the brain, but when humans interpret scans, this only provides a clear diagnosis when dementia is quite advanced. ABATED developed a technology for computerised interpretation of brain scans. This can predict whether somebody with MCD will develop dementia with 92% accuracy.  There is regional variation in dementia diagnosis. East London is very diverse and deprived, with low rates of accurate dementia diagnosis. This study will the technology to interpret the brain scans of people with MCD in East London memory clinics to predict who will develop dementia and who will not.

Chief Investigator: Dr Charles Marshall

Principal Investigator: Dr Georgina Turnbull

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APPLE-Tree

IRAS# 274277

Summary: This study will test a prevention programme to lower older people’s chances of getting dementia. The half of older people (aged 60+) who have problems with “cognition” (memory, orientation and other thinking) have more chance of getting dementia, so we have tried to design an approach that works for them. The programme aims to help older people make changes that can prevent dementia.  The study will find out whether people receiving our programme have less cognitive problems over two years than people who only receive an information leaflet; if so, how our programme worked, and if it is good value for money.

Chief Investigator: Professor Claudia Cooper 

Principal Investigator: Dr Georgina Charlesworth

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Clinical Vignette Study

IRAS# 340105 

Summary: Body dysmorphic disorder (BDD) is common and can have a devastating impact. However, existing data suggest that the condition often goes undiagnosed and untreated. This study will quantitatively examine diagnostic and treatment decision-making among clinicians working in Child and Adolescent Mental Health Services (CAMHS) within the National Health Service (NHS). This study will use a cross-sectional, online survey design. We will aim to recruit five hundred clinicians who will receive two fictional case vignettes. In one vignette the material will describe an adolescent with BDD, and in the other vignette the material will describe an adolescent with obsessive-compulsive disorder (OCD). We will randomly allocate clinicians to receive two vignettes of a cisgender male, or two vignettes of a cisgender female. We will examine clinicians’ accuracy in identifying BDD and OCD from the vignette and whether this varies by the person’s sex. For the BDD vignette specifically, we will explore whether clinician characteristics are associated with diagnostic decisions, and report psychological treatments recommendations. Data will be analysed in an anonymised format and will only be accessed by members of the research team. Only aggregate data will be disseminated outside the team (e.g. publication in peer-reviewed journal, presentation at conferences). This will be the first study to directly assess clinician-reported practices in relation to BDD. The results will provide crucial insight in the training needs of CAMHS clinicians in England, with respect to BDD detection, diagnosis and psychological treatment. This will inform where training is best targeted (e.g. which professional groups) and also shape the content of training (i.e. focus on diagnosis and/or treatment).

Chief Investigator: Dr Georgina Krebs

Local Collaborator: Anna Cattrell         

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ESMI III

IRAS# 265175 

Summary: This study aims produce high-quality evidence about which types of Community Perinatal Mental Health Teams are most effective in improving mother and infant outcomes, and in what circumstances. It will invite 100 pregnant and postnatal women who are receiving services from a perinatal community mental health team, 100 partners/co-parents, and 50 health providers to take part in the study. Women will be invited from different areas in England, from up to 10 different services with different types of provision. Participants will be asked to complete interviews about their experiences of care. Data will also be gathered from services about how many people are referred to the service, the number of sessions attended, and what types of interventions individuals receive. This will inform which types of PMH teams help women and their families get access to evidence-based treatments during pregnancy or postnatally.

Chief Investigator: Abigail Easter

Principal Investigator: Gemma Lutwyche

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FINCH: A crisis planning intervention to reduce compulsory admissions

IRAS# 300671

Summary: The number of people being involuntarily admitted to mental health hospitals under the Mental Health Act (being “sectioned”) has been increasing in the UK. One way to try and reduce this number is to offer support to people who get sectioned to try and reduce the likelihood of it happening again in the future. There is limited research carried out to understand what types of support might help stop or reduce the likelihood of people being sectioned. The aim of this study is to develop and test a new type of support that aims to reduce the likelihood of “sectioning” happening again once someone leaves hospital. The new type of support will involve developing a crisis plan and receiving regular contact from a psychologist over the next year to help people develop skills to manage their own mental health and respond if another crisis may be developing. The study is particularly keen to include and consider how to help people from ethnic minority backgrounds as they are more likely to be “sectioned” compared to White British people.

Chief Investigator: Professor Sonia Johnson

Principal Investigator: Dr Lisa Wood

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RECOLLECT 2

IRAS# 303212

Summary: RECOLLECT stands for Recovery Colleges Characterisation and Testing. It is a programme of research investigating Recovery Colleges. Recovery Colleges are a new approach to supporting people living with mental health problems. They are collaborative, strengths-based, person-centred, inclusive and community-focused. A Recovery College provides support to students (mainly mental health service users but also family members, staff and other stakeholders) through adult education rather than through clinical approaches. The study aims to address how Recovery Colleges can provide the most benefit to people who use mental health services

Chief Investigator: Professor Mike Slade

Principal Investigator: Dr Jacki Stansfeld

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REDUCE Trial: Reducing the impact of DFUs (RCT)

IRAS# 274384 

Summary: Diabetic foot ulcers (DFUs) are poorly healing wounds below the ankle affecting 25% of people with diabetes. Less than half of people will be ulcer-free after 6 months of treatment, and the same number will experience another ulcer within a year.  This study is an intervention to help people with diabetes who have had a foot ulcer previously. It includes 8 one hour session with a healthcare professional, such as a diabetes nurse, and support through a website.  

Chief Investigator: Professor Frances Game

Principal Investigator: Nadine Price

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Remote Approaches to Psychosocial Intervention Delivery (RAPID)

IRAS# 307657

Summary: People with serious mental health problems (SMHP) are more likely to be admitted to psychiatric hospital following contact with crisis services. Pressure on hospital beds is made worse by the extra impact on crisis care, and hospital admissions can be traumatic; because of COVID-19 admitting someone to hospital can be additionally problematic. People with SMHP are vulnerable to COVID-19 due to increased risk of underlying physical health problems, medication effects and engagement with services. There is an urgent need for treatments to address suicidal thoughts/behaviours and reduce avoidable hospital admissions. This study will conduct a multi-site trial to find out which brief and remotely delivered treatments are helpful for people with SMHP with recent suicidal thoughts/suicide attempt.

Chief Investigator: Professor Anthony Morrison

Principal Investigator: Dr Georgina Charlesworth

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Social cognition and functioning in Alzheimer's dementia

IRAS# 313873

Summary: Impaired social functioning is a core feature of dementia and declines progressively through the disease course, but we do not currently understand the specific causes of this decline and have no effective treatments for social functioning. Social cognitive impairment, particularly impaired theory of mind (meaning inability to understand that other people have other thoughts and conceptualise what those thoughts might be), is a likely major cause of this decline and, if this is established, it could be a target for future interventions which aim to maintain social cognition. This study aims to test whether theory of mind deficits, or those in other social cognitive domains, are associated with current and subsequent level of social behaviour and functioning in Alzheimer’s disease. It also aims to establish the reliability and validity of novel approaches to the measurement of social behaviour and function in Alzheimer’s disease.

Chief Investigator: Dr Andrew Sommerlad

Principal Investigator: Jane Burgess

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The Community Navigator Trial

IRAS# 309178

Summary: About a third of people with depression are not helped by anti-depressants and can be termed “treatment resistant” (TRD). Talking therapies are also of limited benefit for this group. Among people with TRD only 2-3 out of 10 recovers over a few years. They are enduringly unwell and often extremely lonely. More research and new types of support are urgently needed for this group. The Community Navigator programme has previously been developed and tested to see if it is feasible and helpful to address loneliness for people with complex depression and anxiety. This study is a full trial in four areas of England to test the effectiveness of the Community Navigator programme, in reducing loneliness and depression for people with TRD in secondary care.

Chief Investigator: Dr Brynmor Lloyd-Evans

Principal Investigator: Emma Barnes

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The PETAL intervention

IRAS# 316749 

Summary: Although aggressive challenging behaviour is highly prevalent in adults with intellectual disability (e.g., 10-25% of adults with mild to severe intellectual disability display aggression), at the moment, there is not a consistent approach to the management of aggression in this population. Aggressive challenging behaviour has a number of consequences in people's lives including reduced quality of life, excessive use of restrictive practices and/or (antipsychotic or psychotropic) medication use, reduced physical safety of the individual or others leading to exclusion from social networks and community facilities and significant economic costs. This cluster randomised controlled trial aims to investigate whether a new multi-component personalised psychosocial intervention is clinically and cost-effective to address aggression (e.g., improved health, better quality of life) in adults with intellectual disability. The PETAL intervention has been co-produced with family carers and adults with intellectual disability alongside researchers and clinicians in intellectual disability. 

Chief Investigator: Angela Hassiotis

Principal Investigator: Dr Bhathika Perera

Borderline Personality Disorder and Eating Disorders: a qualitative investigation of dual diagnoses and service experiences

IRAS# 338919

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Cognition and Social Functioning in Non-Affective Psychosis

IRAS# 349312

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Efficacy of Online Imaginal Exposure Therapy for Individuals with Anorexia Nervosa

IRAS# 328408

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Exploring staff experiences of racial abuse from patients within an acute inpatient setting

IRAS# 354523

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Exploring the experience of support workers and managers supporting people with learning disabilities who have moved from inpatient to community settings as part of the Transforming Care Agenda.

IRAS# 339318

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Measuring What Matters to Young People in Inpatient Mental Health Services: The development of a questionnaire

IRAS# 343607

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Patient care, the patient’s way: An evaluation of Method of Levels therapy in secondary care

IRAS# 266408

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The role of self-compassion in the relationship between the eating disorder critic and eating disorder behaviours.

IRAS# 335128

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Transcutaneous blood gas (TCBG) analysis: Are transcutaneous blood gases a reliable alternative to capillary blood gas sampling, in the context of Long Term Oxygen Therapy Assessment (LTOT) adults, in a community setting?

IRAS# 305136