About Sickle Cell

Sickle cell disease (SCD) represents a group of inherited disorders that impact haemoglobin, the protein found in red blood cells that is essential for oxygen transport throughout the body. In individuals diagnosed with SCD, the haemoglobin is altered, resulting in red blood cells that become rigid, sticky, and assume a crescent or "sickle" shape. This abnormal morphology can lead to obstructions in small blood vessels, thereby hindering the proper flow of blood and the delivery of oxygen to various tissues and organs.

Triggers

  • Sudden changes in weather
  • Dehydration
  • Infection
  • High Altitude
  • Extreme Cold
  • Extreme Hot weather
  • Overexertion
  • Alcohol
  • Smoking
  • Swimming

Medications

Penicillin Prophylaxis

Penicillin V should be offered to all children according to the following dosage schedule:

  • 125mg po bd from 3 months -5yr
  • 250mg po bd >5yr

Erythromycin is a suitable alternative if a documented penicillin allergy is present.

Folic acid-2.5mg from 3 months and 5mg at age 5

Immunisations

Sickle cell vaccine chart